Well, I think its not a total waste of your time if you keep sending supportive emails to these inactive affiliates.
They all have challenges, reasons, and/or excuses why they didn't follow through after signing up and as such, in the interim, all you can do as their sponsor or co-sponsor, is to keep sending valuable information to your down-line as you never know when one or some of them may find what you sent inspiring, and become very active.