The biggest mistake in advertising is trying to sell something! People have a built-in "wall" when it comes to advertising. If they only see someone that is trying to get them to give up their hard-earned cash, they will tune you out within 5 seconds!
Depending on the type of advertising, don't sell a product, offer a solution! You are not advertising to make money, you are advertising to help solve a problem! That's the mindset to take to your ad.